專家研究稱：流感可能與阿爾茨海默癥有聯系
The Flu May Cause Alzheimer's
譯文簡介
科學家們開始發(fā)現阿爾茨海默病、帕金森病、肌萎縮側索硬化癥（ALS）、多發(fā)性硬化癥（MS）和癡呆癥等神經退行性疾病之間存在一種奇特聯系，這些疾病似乎都在常見但嚴重的感染之后出現，這意味著我們可能有機會阻止這些疾病的發(fā)生。
正文翻譯
近年來，關于神經退行性疾病發(fā)病機制的研究揭示了一個引人注目的方向：常見病毒感染與阿爾茨海默病、帕金森病、肌萎縮側索硬化癥等疾病之間可能存在潛在關聯。傳統觀點認為這些疾病是年齡增長過程中不可避免的后果，但流行病學數據與生物學機制研究正在挑戰(zhàn)這一認知。多國大規(guī)模健康數據庫的長期追蹤顯示，經歷流感、肺炎、帶狀皰疹等嚴重感染的患者，在后續(xù)數年至數十年間罹患神經退行性疾病的風險顯著提升。一項覆蓋30萬芬蘭居民的隊列研究發(fā)現，因病毒性腦炎住院的患者后期阿爾茨海默病發(fā)病率激增22至30倍，類似的關聯模式在跨地區(qū)驗證中展現出統計學穩(wěn)定性。
這種延遲性效應引發(fā)了關于病理機制的深入探討。目前兩種假說受到學界關注：其一，神經嗜性病毒可能通過直接入侵中樞神經系統觸發(fā)持續(xù)炎癥反應，例如單純皰疹病毒（HSV-1）在潛伏與復發(fā)的循環(huán)中刺激β淀粉樣蛋白異常沉積，這一過程在小鼠模型中已被觀察到可加速神經退行進程；其二，病毒感染可能永久性改變宿主細胞的蛋白折疊系統，導致細胞器在清除病毒后仍持續(xù)錯誤組裝內源性蛋白，形成病理性斑塊。支持性證據來自HIV藥物研究，某些抗病毒制劑意外展現出延緩ALS患者蛋白聚集的作用，提示病毒復制機制與神經退行過程可能存在分子層面共性。
預防醫(yī)學領域為此提供了間接佐證。流感疫苗、肺炎疫苗的廣泛接種不僅降低目標感染發(fā)生率，同時關聯人群的神經退行性疾病發(fā)病率呈現下降趨勢。這種現象可能與疫苗減輕感染嚴重程度有關——需要住院治療的嚴重感染患者神經退行風險最高，而疫苗通過降低重癥轉化率間接切斷這一病理鏈條。值得注意的是，這種保護效應具有廣譜性，不同病毒疫苗對應多種神經退行疾病風險的同步下降，提示感染引發(fā)的系統性炎癥或神經損傷可能是共同致病通路。
盡管因果關系的最終確立仍需長期觀察，特別是新冠肺炎大流行為研究急性病毒感染與慢性神經退行過程的關系提供了自然實驗場，但現有證據已足夠推動公共衛(wèi)生策略調整。加強呼吸道病毒、皰疹病毒等常見病原體的免疫防護，開發(fā)針對神經嗜性病毒的特異性療法，可能成為預防神經退行性疾病的新突破口。從臨床實踐角度看，對嚴重感染患者實施長期神經功能監(jiān)測，結合抗病毒藥物與神經保護劑的協同干預，或將為延緩疾病進展提供新思路。隨著分子檢測技術的進步，未來有望通過檢測特定病毒抗體滴度或神經炎癥標記物，建立個體化風險評估體系，在癥狀出現前啟動針對性預防措施。
這一研究方向的突破性在于重構了慢性病與急性感染之間的關聯，將神經退行性疾病的防治窗口前移數十年。如果后續(xù)研究能確證病毒感染的核心致病作用，意味著人類可能通過完善現有疫苗體系與抗病毒治療方案，顯著降低這類毀滅性疾病的負擔。盡管具體機制解析與臨床轉化仍需時日，但將神經退行性疾病納入感染后并發(fā)癥管理范疇，已為對抗這些曾被視為"不可避免"的老年疾病開辟了充滿希望的新路徑。
這種延遲性效應引發(fā)了關于病理機制的深入探討。目前兩種假說受到學界關注：其一，神經嗜性病毒可能通過直接入侵中樞神經系統觸發(fā)持續(xù)炎癥反應，例如單純皰疹病毒（HSV-1）在潛伏與復發(fā)的循環(huán)中刺激β淀粉樣蛋白異常沉積，這一過程在小鼠模型中已被觀察到可加速神經退行進程；其二，病毒感染可能永久性改變宿主細胞的蛋白折疊系統，導致細胞器在清除病毒后仍持續(xù)錯誤組裝內源性蛋白，形成病理性斑塊。支持性證據來自HIV藥物研究，某些抗病毒制劑意外展現出延緩ALS患者蛋白聚集的作用，提示病毒復制機制與神經退行過程可能存在分子層面共性。
預防醫(yī)學領域為此提供了間接佐證。流感疫苗、肺炎疫苗的廣泛接種不僅降低目標感染發(fā)生率，同時關聯人群的神經退行性疾病發(fā)病率呈現下降趨勢。這種現象可能與疫苗減輕感染嚴重程度有關——需要住院治療的嚴重感染患者神經退行風險最高，而疫苗通過降低重癥轉化率間接切斷這一病理鏈條。值得注意的是，這種保護效應具有廣譜性，不同病毒疫苗對應多種神經退行疾病風險的同步下降，提示感染引發(fā)的系統性炎癥或神經損傷可能是共同致病通路。
盡管因果關系的最終確立仍需長期觀察，特別是新冠肺炎大流行為研究急性病毒感染與慢性神經退行過程的關系提供了自然實驗場，但現有證據已足夠推動公共衛(wèi)生策略調整。加強呼吸道病毒、皰疹病毒等常見病原體的免疫防護，開發(fā)針對神經嗜性病毒的特異性療法，可能成為預防神經退行性疾病的新突破口。從臨床實踐角度看，對嚴重感染患者實施長期神經功能監(jiān)測，結合抗病毒藥物與神經保護劑的協同干預，或將為延緩疾病進展提供新思路。隨著分子檢測技術的進步，未來有望通過檢測特定病毒抗體滴度或神經炎癥標記物，建立個體化風險評估體系，在癥狀出現前啟動針對性預防措施。
這一研究方向的突破性在于重構了慢性病與急性感染之間的關聯，將神經退行性疾病的防治窗口前移數十年。如果后續(xù)研究能確證病毒感染的核心致病作用，意味著人類可能通過完善現有疫苗體系與抗病毒治療方案，顯著降低這類毀滅性疾病的負擔。盡管具體機制解析與臨床轉化仍需時日，但將神經退行性疾病納入感染后并發(fā)癥管理范疇，已為對抗這些曾被視為"不可避免"的老年疾病開辟了充滿希望的新路徑。
評論翻譯
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If viral infections in adults increases chances of neurodegenerative diseases in adults what about in children?
Asking as someone who had mono in Pre-K.
如果成年人的病毒感染會增加患神經退行性疾病的風險，那兒童的情況如何？作為在學前班得過單核細胞增多癥的人，我想知道這個問題的答案。
Virus infections, like the flu, can cause a lot of later illnesses. Hashimoto might also get triggered by such.
病毒感染（比如流感）可能引發(fā)多種后續(xù)疾病，橋本甲狀腺炎也可能因此被誘發(fā)。
Go figure, another case of prevention is better and likely cheaper than treatment.
不出所料，這又是一個證明預防勝于治療且成本更低的案例。
As someone who got COVID twice, and also got the vaccines , this is pretty sucky to hear
作為感染過兩次新冠且接種過疫苗的人，聽到這個消息真是糟心。
My family always believed my father got Alzheimers due to a severe bout of Scarlet fever as a child.
我家一直認為，父親患阿爾茨海默病是因為他小時候得過嚴重的猩紅熱。
Vaccines truly are one of the most beneficial inventions in human history.
疫苗確實是人類歷史上最偉大的發(fā)明之一。
So because I caught the flu at 22 I need to think about catching Alzheimers someday?
所以，就因為我22歲時得過流感，現在就得擔心未來會得阿爾茨海默??？
A super worrying video title for me who's caught some sort of respirotary viral infection every month since September; I'm literally sick every month.
這個視頻標題讓我極度焦慮——自九月起，我每月都會感染某種呼吸道病毒，字面意義上每個月都在生病。
原創(chuàng)翻譯：龍騰網 http://www.top-shui.cn 轉載請注明出處
Viruses are lixed to many diseases. They really arent benign and should be avoided if possible. Vaccines could save you from more than the initial infection.
病毒與多種疾病相關，它們絕非無害，應盡可能避免感染。疫苗不僅能預防初次感染，還能提供更多保護。
My older brother gave me cold sores as a baby. My mom kept telling him not to kiss me, but he did anyway. I'm pretty upset about it as I was a completely helpless baby who couldn't consent and now I have to live with this for the rest of my life. Stg that if I get any kind of dementia from it...
我哥哥在我嬰兒時期把唇皰疹傳染給了我。媽媽反復提醒他別親我，但他還是做了。這件事讓我很生氣，畢竟我當時毫無反抗能力，現在卻要終生承受后果。要是因此患上癡呆癥，我發(fā)誓...
I luckily don't plan to live so long that I'd get Parkinson's. But also how do people even get the Flu. Like I had C*vid several times and some really bad colds but never a flu, idk how people have it every year.
幸好我不打算活到會得帕金森病的年紀。不過話說回來，人們到底是怎么得流感的？我感染過幾次新冠和重感冒，但從沒得過流感，實在不懂為什么有人每年都中招。
Dirty teeth and strep throat cause neuro and cardiac diseases.
牙齒不潔和鏈球菌性咽喉炎會引發(fā)神經與心臟疾病。
Great video.
Vaccination and treatments are definitely vital- but why neglect to mention respirator masks and clean are as preventive measures? Both are easy and effective ways to lower tve risk of infection and lower viral loads.
視頻很棒。疫苗接種和治療當然重要，但為什么不提呼吸器口罩和清潔空氣作為預防措施？這兩者都是降低感染風險和病毒載量的簡便有效方法。
Damn, great news to hear when my mom is antivax and I got the flu every single year not to mention the terrible brain fog I've got now. It feels like I'm a different person now, my capabilities are just so different.
真諷刺，我媽是反疫苗人士，而我每年都得流感，更別提現在嚴重的腦霧。感覺像是變了個人，能力完全不同了。
Youre telling me that having a severe infection that beats the crap out of your brain could potentially lead to your brain breaking down later in life? SHOCKER. Truly, a revolutionary epiphany.
(Could you feel the sarcasm in there? Because I REALLY really meant it.)
你是說嚴重感染把大腦折騰得半死，可能導致晚年腦功能衰退？天吶，這真是顛覆性發(fā)現啊。（感受到我的諷刺了嗎？因為我真的就是這個意思。）
I wonder how many studies are/will look at these diseases conecting to Covid
不知道有多少研究正在或將會探索這些疾病與新冠的關聯。
Wear your respirators people! Good quality masks will save your life and brain.
大家戴好呼吸器吧！優(yōu)質口罩能拯救你的生命和大腦。
Nice to hear some positive news in the world of public health I didnt expect to see anything for 4 years while the Secretary of Health and Human Services has the nations collective head in the sand.
聽到公共衛(wèi)生領域的好消息真不錯。過去四年衛(wèi)生與公眾服務部長讓全國集體逃避現實，我本不指望能看到任何進展。
One paper I read had the theory that each flu/bad cold kills some neurons. This is okay, but with getting sick over the years, the loss of neurons adds up until it isn't okay (heavily paraphrased). Regardless, you could say that it is a lack of fitness, because fit people get sick less. See: "A 2024 study found that people who exercise regularly are much less likely to get COVID-19 or be hospitalized with it, compared with people who don't exercise regularly." The new hotness is Alzheimer's is a vascular disease. So, virus or fitness, either way exercise is the solution.
我讀過一篇論文提出理論：每次流感/重感冒會殺死部分神經元。這暫時沒問題，但多年累積的神經元損失終將引發(fā)問題（大意如此）。不管怎樣，可以說這是缺乏鍛煉的結果，因為健康人群患病更少。參考："2024年研究發(fā)現，定期鍛煉者感染新冠或住院的概率遠低于不鍛煉者"。最新觀點認為阿爾茨海默病是血管疾病。所以無論病毒還是體質，鍛煉都是解決之道。
Flu injections don't stop the infection only lessons the symptoms & duration so the working don't take as much time off. To some it doesn't affect the virus at all. Specifically where the autoimmune system attacks everything, good or bad.
流感疫苗不能阻止感染，只能減輕癥狀和縮短病程，讓打工人少請病假。對某些人（尤其是免疫系統無差別攻擊的人群）來說，疫苗對病毒完全無效。
The fact that spike protein can lead to rapid onset vascular dementia was very helpful to eliciting this!
刺突蛋白可能導致快速發(fā)作的血管性癡呆，這一事實對引發(fā)此研究非常關鍵！
It would be great to include non pharmaceutical interventions as prevention as well! Respirators, air purifiers, and paid sick leave all make meaningful differences in breaking chains of transmission.
若能納入非藥物干預作為預防措施就更好了！呼吸器、空氣凈化器和帶薪病假都能有效阻斷傳播鏈。
I dont get the flu, covid, or mono since I wear n95 masks. I dont get herpes for another reason
自從戴N95口罩后，我沒得過流感、新冠或單核細胞增多癥。至于皰疹...沒得是另有原因。
Studies and people have been yelling about it since like the first year of covid. Luckily masks are effective against all of them especially the flu
從新冠爆發(fā)第一年起，研究和民眾就在呼吁這事。幸好口罩對所有病毒都有效，尤其是流感。
My grandparents both had dementia, got their flu shots every year, and were never sick. Viruses like the flu, mono, and HSV-1 are so common, how can you reliably make a connection? You can find data, and anecdotes, supporting either way.
我祖父母都患癡呆癥，每年接種流感疫苗且從不生病。流感、單核細胞增多癥和HSV-1病毒如此普遍，如何建立可靠關聯？正反兩面的數據和案例都能找到。
Keep in mind that there are other post viral infections that can cause similar symptoms, many people that have ME/CFS developed that disease after an Epstein-Barr infection that disease causes brain fog and severe fatigue and muscle and neurological symptoms so this is not a stretch at all to patients that are familiar with me/cfs and similar conditions. Furthermore, that disease has been so grossly ignored underfunded, and un research for literally decades. How much further would we be in other medical research if somebody had paid attention to all the patients that have been begging for help its such a complex disease with so many different facets that its turning out that theres lixs and similarities to so many other major conditions. That is the only bright spot coming off of Covid is that people are finally starting to pay attention and looking at ME/CFS and long Covid research.
請記住，其他病毒感染后遺癥也會引發(fā)類似癥狀。許多ME/CFS（肌痛性腦脊髓炎/慢性疲勞綜合征）患者是在EB病毒感染后發(fā)病的，該疾病會導致腦霧、嚴重疲勞及肌肉神經癥狀。因此，對熟悉ME/CFS的患者來說，這種關聯并不牽強。更何況，這種疾病數十年來一直被忽視、資金不足且缺乏研究。若當初有人關注過這些求助的患者，其他醫(yī)學研究領域本可取得更大進展——該病如此復雜，涉及多個層面，現已發(fā)現與多種重大疾病存在關聯。唯一的好消息是，新冠讓人們終于開始重視ME/CFS和長新冠研究。
I guess well have to hope some other nation finds out about this and tells us in America.
看來我們只能指望其他國家先發(fā)現真相，再來告訴美國了。
Too bad that in the USA they're actually talking about taking away funding for flu vaccines and a meeting was just canceled regarding the next seasonal flu vaccine
可悲的是，美國居然在討論削減流感疫苗資金，連下季流感疫苗的會議都被取消了。
原創(chuàng)翻譯：龍騰網 http://www.top-shui.cn 轉載請注明出處
But arent people who are elderly now a well-vaccinated group?
但現在的老年人不正是疫苗接種率較高的群體嗎？
They should get a dataset from Japan. A country were vaccination and mask wearing while ill is common. I would suppose the relationship between infections and NDDs would be more obvious.
他們應該采用日本的數據集。這個國家疫苗接種率高，生病時戴口罩很普遍。我猜感染與神經退行性疾病的關系會更明顯。
I cant stop relating this to prions for some reason. Its improperly folded goo lol
不知為何，我總聯想到朊病毒。都是錯誤折疊的蛋白質糊狀物啊，哈哈。
原創(chuàng)翻譯：龍騰網 http://www.top-shui.cn 轉載請注明出處
Childfree people could be useful in trials. I get WAY fewer viruses than my siblings with kids. And my parents with grandkids. Probably a quarter of the frequency which is a lot of flus over a lifetime.
沒有孩子的人可能在臨床試驗中很有用。與有孩子的兄弟姐妹相比，我感染病毒的頻率低得多，連有孫輩的父母也是如此。我的感染率大概是他們的四分之一，這相當于一生中少得很多次流感。
shout-out to all my fellow flu sufferers!
i got the flu vaccine, still got it, but let's hope we don't get alzheimers until we're 105!
向所有和我一樣被流感折磨過的戰(zhàn)友們致敬！雖然打了疫苗還是中招了，但希望我們至少能撐到105歲再得老年癡呆吧！
While at the same time the US government is cutting research funding ....
然而與此同時，美國政府卻在削減研究經費......
I've never had the flu.im 67years old.dont know why.never had a flu prick. And no covid. Tested 5 times family positive me negative. Negative. How.
我今年67歲，從沒得過流感，也不知道為什么。沒打過流感疫苗，也沒感染過新冠——家人陽性時我測了五次都是陰性。這到底怎么回事？
Pneumonia vaccine is protective against Streptococcus Pneumoniae, a bacteria not a virus.
肺炎疫苗針對的是肺炎鏈球菌，這可是細菌不是病毒，這點要澄清清楚。
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This is what ME/CFS researchers have been saying for a decade now. Glad to see it being picked up.
肌痛性腦脊髓炎/慢性疲勞綜合征（ME/CFS）的研究者們十年前就在說這個了，很高興終于有人關注到。
Sorry but I think whatever sets off the NDD is contagious AND the NDD and some cancers are contagious too.
雖然聽起來很離譜，但我懷疑不僅是觸發(fā)神經退行性疾病的因素具有傳染性，連這些疾病本身和某些癌癥也可能傳染。
Yet another reason why getting vaccinated and wearing a mask is so important!
這又給了我們一個接種疫苗和戴口罩的重要理由！
If only there was a way to make your doctor take your symptoms seriously before its too late :(
要是在為時已晚之前，能有辦法讓醫(yī)生認真對待我們的癥狀就好了
Oh that's great to see pop up in my recommendations while I'm battling the worst flu I've ever had.
真棒，在我經歷人生最嚴重流感時，這個視頻出現在推薦列表里。
i am lying on the couch with the flu....not a video i wanted to see.
此刻正因流感癱在沙發(fā)上的我...真不想刷到這個視頻。
Ah, thanks... I thought this would be about flu (which I've only ever had a couple of times).
Instead, it's about a number of illnesses - including Shingles, which has been reinfecting me for over 40 years, and Mono, which put my son in hospital.
I wish I hadn't clicked on this now
啊，謝謝...我還以為視頻主要講流感（我只得過兩三次）。結果內容涉及多種疾病——包括困擾我40多年的帶狀皰疹，還有讓我兒子住院的傳染性單核細胞增多癥?，F在真后悔點開這個視頻。
Highly speculative. The video presenter is correct that highly prent diseases could correlate to a lot of things, and being able to reproduce the result across different countries reduce the odds of that a bit; but they're talking about over 40 types of common viral infections, and a lot of people get these infections across all countries, so reproducing the results across countries is not enough to rule out the possibility that the correlation is spurious. This video makes it sound like we have pretty good reasons to think that viral infections cause NDD's, but it seems far from it. It doesn't help science when the media over-sell scientific results. Let science do its job.
What is a regular person supposed to do with this piece of information? Freakout a bit whenever they get hospitalized by the flu? And what would that be based on? Correlative data that's still getting vetted? I think it's fine to release news for the sake of entertainment ... but the headline for this video is saying "X could be the CAUSE for one of the most terrifying disease you'll ever face", and that seems more like a headline designed to inform and raise awareness, as if people need to take public action.
The last point I want to make is this video should be more careful about statements of "causation". What we have here is statistical correlation, and correlation is still a powerful reason to take action when there's enough scrutiny and data, but if we do not have confidence in knowing the mechanisms for causation ... then it's NOT a causal theory. It's still just correlation dressed in the word "cause", which often makes people feel more justified in their beliefs than perhaps they should be (feeling justified to take extreme actions or inaction). The word "cause" is a powerful idea, and we should not abuse it.
這個推論太牽強。視頻主講人說得對，流行疾病可能與許多事物存在相關性，跨國驗證結果確實能降低偶然性，但他們討論的是40多種常見病毒感染，且這些感染在全球范圍都很普遍，因此跨國驗證并不足以排除偽相關可能。視頻給人"病毒感染導致神經退行性疾病"證據確鑿的錯覺，但事實遠非如此。媒體過度炒作科學發(fā)現對科研無益，應該讓科學自己說話。
普通人該如何處理這種信息？每次因流感住院就恐慌？這種恐慌的依據是什么？尚未驗證的相關數據？我覺得作為娛樂新聞發(fā)布沒問題...但視頻標題卻寫著"X可能是你最恐懼疾病的元兇"，這更像是為提升公眾意識設計的警示性標題。
最后要指出，視頻使用"因果關系"的說法不夠嚴謹。我們目前只有統計相關性，雖然足夠的數據支持下相關性可作為行動依據，但若無法明確機制，就不能稱為因果理論。用"導致"包裝相關性，容易讓人產生錯誤認知（比如采取極端行動或消極應對）。"導致"這個詞具有強大暗示性，不應濫用。
Not at all the video title I wanted to see, mindlessly scrolling through my feed in a flu-induced haze
在流感導致的昏沉中無意識刷著推薦頁，這絕對是最不想看到的標題。
Just got the flu for the first time in my life, why youtube?
人生第一次得流感，油管你為什么要這樣對我？
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I was JUST reading a paper about this possible lix - in relation to West Nile Virus and NDD's - and it referred back to the studies about Influenza and ESBV @.@ Then y'all post this! We are on the same brainwave!!! [And I was looking into it, after the video you guys posted about Chronic Fatigue Syndrome!]
我剛在讀關于西尼羅河病毒與神經退行性疾病關聯的論文，文中引用了流感和EB病毒的研究，結果你們就發(fā)了這個視頻！我們腦電波同步了！?。。ㄎ疫€是在看了你們發(fā)布的慢性疲勞綜合征視頻后才開始研究的?。?/b>
My grandma got the flu shot every year. The last one she got caused an auto immune reaction that left her almost entirly paralized. All she could do was moan for the next two years until she passed.
3 independent doctors verified this is what happens and my grandfather is still stuck in legal battles because the state is acting like she was in poor health prior. (Once again 3 different doctors independently verified it was the shot.)
I haven't gotten one after that and i don't plan on it. Its kinda horrifying. I think it would be an interesting video sybject in general
我奶奶每年都打流感疫苗，但最后一針引發(fā)了自身免疫反應，導致她幾乎全身癱瘓。接下來的兩年里她只能呻吟度日，直到去世。
三位獨立醫(yī)生都確認了這個診斷，但政府堅稱她原本健康狀況就不好，祖父至今仍在打官司（再次強調，三位不同醫(yī)生獨立驗證是疫苗導致的）。
此后我再沒打過流感疫苗，也不打算打。這件事太可怕了，感覺可以單獨做期視頻來講。
This is just an anecdote, of course, but my grandmother got shingles (caused by varicella zoster virus) and seemingly straight after developed Alzheimer's disease.
雖然只是個例，但我奶奶得帶狀皰疹（水痘-帶狀皰疹病毒引起）后，緊接著就患上了阿爾茨海默癥。
This makes so much sense! As someone on year...?17? of "living" with ME/CFS I really hope they figure this stuff out quickly. If they can save my son(whose immune system seems very similar mine) from having to go down the same path as me I'll consider that a win. Thankfully he's already got more vaccines than were available to me growing up, and he's not being put through the trauma I was, but it's those epigenetic markers that have me worried.
這完全說得通！作為與ME/CFS共處...17年？的患者，我真心希望研究能快速突破。如果能讓我兒子（他的免疫系統和我很像）免于重蹈覆轍，我就心滿意足了。慶幸的是他現在能接種的疫苗比我小時候多得多，也沒經歷我受過的創(chuàng)傷，但那些表觀遺傳標記還是讓我擔心。
Everybody gets the flu? Everybody gets mono? Everybody gets herpes? I've never had mono or herpes.
誰說人人都得過流感？都得過單核細胞增多癥？都得過皰疹？我這兒可沒得過單核細胞增多癥，皰疹也沒沾過邊。
Take it from my sister: You can't get Alzheimer's if you've got sawdust for brains.
我姐說了：只要你腦袋里裝的是鋸末，就不用擔心得阿爾茨海默癥。
I am buying the causal lix. There is Prion disease, which were called "slow viruses" when they were first noticed. The pathology of the diseases are characterized by a build up of plaque in the brain. If memory serves, the plaque is simply a protein string that is folded in an unusual way. The question is how and why does a malformed protein string replicate itself. Viruses hijack a particular cell's replication mechanism. Protein string don't do that.
我完全相信這種因果關系。朊病毒病剛被發(fā)現時被稱為"慢病毒"，其病理特征就是大腦中斑塊的堆積。雖然記憶可能不準確，但斑塊其實就是一種以特殊方式折疊的蛋白質鏈。問題在于這種錯誤折疊的蛋白質鏈如何以及為何會自我復制。病毒會劫持特定細胞的復制機制，但蛋白質鏈可不會這么干。
Thats like saying eating breakfast MAY cause car crashes ? (because many accidents happen in the morning, after people had breakfast)
這就好比說"吃早餐可能導致車禍"（因為很多事故都發(fā)生在人們吃完早餐的早晨）一樣荒謬。
Probably used to know this, but I had an outbreak of flu last week.
這些知識我以前可能學過，但上周得了流感之后全忘光了。
Honestly just reducing these deseases could be huge. I've loast a few people to them and they are such a hard way to loose someone.
說真的，只要能減少這些疾病就是重大突破。我因此失去了好幾位親友，這種失去方式實在太煎熬了。
Severe enough infections that can warrant a trip to the hospital where medications are administered. Weird that the possibility of an exposure to certain medications wasnt discussed as a possible cause
需要住院治療的嚴重感染本身就涉及藥物使用，奇怪的是視頻居然沒討論接觸某些藥物作為潛在致病因素的可能性。
I...uh...never had mono. But I have MS. I also don't know if I've ever gotten the flu. If so, it would have been so far back into my childhood that I have no memory of it.
我...呃...從沒得過單核細胞增多癥，但有多發(fā)性硬化癥。至于流感，就算小時候得過也完全沒印象了。
What a wonderful time to have a new head of the American HHS who is shutting down vaccine programs
美國衛(wèi)生與公眾服務部新部長正在關閉疫苗項目，這時間點選得可真"妙"啊。
Lol viruses dont "cause" them, it's a correlation because the viruses rely on our mitochondria. NDD's are caused by all the negative affects of faulty mitochondria. You're all at a much higher risk than you think.
笑死，病毒不是"導致"這些病，只是相關而已，畢竟病毒依賴我們的線粒體。神經退行性疾病其實是故障線粒體帶來的各種負面影響造成的，各位的實際風險比想象中高得多。
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I'm betting that we'll find a political correlation between conservative views and increased NDDs over the next few decades. They sure have taken up the mantle of vaccine rejection.
我敢打賭，未來幾十年我們會發(fā)現保守派觀點與神經退行性疾病增加存在政治關聯。畢竟他們可是把反疫苗的大旗扛得穩(wěn)穩(wěn)的。
Please let me know if I just missed this! What if the people who are susceptible to severe infections are also just more susceptible to dementia and Alz? Eg: genetic predisposition to both conditions independently, or an autoimmune disease that could cause both more severe infection and also attack the brain.
要是我漏看了請指正！有沒有可能易受嚴重感染的人群本身就更容易患癡呆和阿爾茨海默？比如存在獨立遺傳傾向，或某種既會導致嚴重感染又會攻擊大腦的自身免疫疾??？
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I bet in some years they'll discover that the flu prevents NDDs.
我賭過幾年他們又會發(fā)現流感能預防神經退行性疾病。
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I recall Dr Michael Greger stating there was a longer life connection amongst those who got flu shots. Makes sense.
我記得Michael Greger博士說過接種流感疫苗與長壽存在關聯，這么看來確實合理。
Just wait until they see what covid did to all of our brains. I have for sure had a deminished mental state since having covid the second time. My words dont come to me as they used to, and I stumble over words when speaking and listening now.
等著看新冠對我們大腦的長期影響吧。自從二次感染后，我的認知能力明顯下降，現在說話找詞困難，連聽人講話都會卡殼。
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I now, very much regret not getting flu shots (since I am deathly afraid of needles) Then again its not like Ive actually been getting the flu, as far as I know I suppose Ill be changing that habit of not getting the shot
現在超后悔沒打流感疫苗（雖然我暈針），不過話說回來，據我所知我也沒怎么得過流感?？磥淼酶母倪@個不打疫苗的毛病了。
One must be able to afford health care before this means anything.
得先看得起病，這些研究結論才有意義啊。
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Just thinking out loud: could severe viral infections also be related to other chronic diseases like arthritis, RA, cataracts, diabetes?
隨便想想：嚴重病毒感染會不會也與其他慢性病有關？比如關節(jié)炎、類風濕、白內障、糖尿病？
why is this getting shown just right now as i have the flu the first time in ages.
為啥偏偏在我多年不遇得流感的時候，給我推這個視頻？
The flu isn't a stomach virus. What people call the stomach flu can be viral gastroenteritis. Influenza is a whole body illness.
流感不是腸胃病毒。人們說的"腸胃型流感"其實是病毒性腸胃炎，真正流感是全身性疾病。
As someone who after COVID suddenly has new chronic conditions that have greatly impacted my quality of life (my esophagus no longer contracts when I eat for example), who also JUST had the flu for the first time, I regret watching this lmfaoooo such a fascinating topic though.
作為新冠后突發(fā)多種慢性?。ū热缡车朗ナ湛s功能）又剛經歷人生首次流感的人，看完這個視頻真是悔不當初哈哈，雖然話題確實引人入勝。
What if it was as simple as improving your microbiome? There is plenty of research to suggest that these flu viruses interrupt the microbiome(especially Covid). So instead of getting multiple vaccinations you just focused on restoring or endlessly improving the microbiome.
要是改善腸道菌群就能解決問題呢？大量研究表明流感病毒（尤其是新冠）會破壞菌群?；蛟S比起不停打疫苗，專注修復和優(yōu)化菌群更有效？
feeling really blessed right now to have a congenital heart defect which puts me on the free yearly flu shot list
突然覺得先天性心臟缺陷真是"福氣"——能享受免費年度流感疫苗。
Big pharma entered your feed. You're fine, people. Watch your diet.
大藥廠開始操控推送了。別慌各位，注意飲食就行。
i know vaccines don't cause autosm, but in the wild, infinitesimally small chance than it does, i'd rather be socially awkward and hyper fixated on star trek than have alzheimer's
雖然疫苗不會導致自閉癥，但就算有億萬分之一的可能，我寧愿做個沉迷《星際迷航》的社交怪人，也不想得阿爾茨海默癥。
Having suffered with the flu myself i was worried so i did a thousand page thesis on this very subject. I can't remember where i put it.
得過流感后太擔心，于是寫了千頁論文研究這個課題?，F在？完全記不得論文放哪了。（玩梗）
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I understand that we do human trials before releasing it to the general public, but doesn't testing on rats not skew data between species? No medicine is a one size fits all. There's always outliers.
理解新藥上市前要做人體試驗，但用老鼠做實驗不會導致跨物種數據偏差嗎？畢竟沒有萬能藥，總有特例存在。
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So don't get the flu. There are better ways to avoid the flu than to get a vaccine. At least for most people.
所以別得流感就行。對多數人來說，不打疫苗也有更好的預防方式。
We don't know yet if the plaques are a cause or a result of these conditions and their symptoms, unless my info is out of date? Lots of people on autopsy have a f-tonne of amaloid plaques but no symptoms of Alzheimers or anything else
斑塊到底是病因還是病癥表現？據我所知（可能過時了），很多尸檢發(fā)現大量淀粉樣斑塊的人生前根本沒阿爾茨海默癥狀。
how about his hypothesis for connecting those seemingly unrelated facts. What if healthy people, which take care of themselves and their body, have a tendency of having less diseases, either flu or alzheimer's. and people which doesn't take proper case of their body and health will end up with more flu throughout their life and alzheimer's?
他這個關聯看似無關事實的假說如何？或許注重養(yǎng)生的人本就較少患病（無論是流感還是阿爾茨海默），而不重視健康的人既容易得流感，晚年也易患癡呆？
Getting neurodegenerative diseases is definitely the worst nightmare for me. If only we had effective measures to prevent infection - such as cheap and easily available masks. Oh no. (Plus, given the infection mode of SARS-CoV-2, you really also don't want LongCovid since even mild or asymptomatic infections can cause it, and even vaccination only reduces the risk but doesn't eliminate it.) Demand cleaner air.
患上神經退行性疾病絕對是我的終極噩夢。要是有便宜易得的口罩這類有效防感染措施就好了。更別提新冠病毒的傳播方式——你絕對不想得長新冠，因為就算輕癥或無癥狀感染也可能中招，疫苗也只能降低風險而非杜絕。我們需要更潔凈的空氣！
Maybe people who bother to get vaccines also take other protective health precautions like Vigorous exercise and eat healthy foods.
或許愿意接種疫苗的人本身就更注重健康防護，比如堅持鍛煉和健康飲食。
I am definitely still dealing with an amount of brain fog about a week after the flu now. Hopefully that gets better over time.
流感痊愈一周了，腦霧癥狀依然存在，但愿能隨時間改善。
There is a difference between things you get vaccinated for and you're all good, and things that require the majority of the population to get vaccinated for. The video didn't go into that at all, and at this point it doesn't seem like we'll be getting herd immunity on any new diseases going forward. FML
個人接種就有效的疫苗和需要群體免疫的疫苗是兩碼事。視頻完全沒提這點，而照現在這趨勢，新疾病就別指望群體免疫了。真是日了狗了。
But? But? Didnt your President simply advise everyone to inject bleach?
等等？你們總統不是建議全民注射漂白劑嗎？
THis is a great counter argument to those idiot anti vaxxers who think theyd rather just tough it out with viral infections
這可是打臉那些寧愿硬扛病毒感染的反疫苗蠢貨的絕佳論據。
Problem is you need to get vaaxed every 3 months for covid. Hardly anyone is doing that. Vaccine only is a strategy but combine it with clean air, n95s and healthy life style massively reduces the risk
問題在于新冠疫苗需要每三個月接種一次，但幾乎沒人這么做。單靠疫苗是不夠的，必須結合潔凈空氣、佩戴N95口罩和健康生活方式才能大幅降低風險。
Herpes is not deadly, so that is why nobody ever bothered to find a vaccine or cure. That makes me angry. But perhaps it will be beneficial for society to actually work on a cure, now that there is a lix to deadly and costly diseases. I look forward to getting a cure.
皰疹本身不致命，所以沒人費心研發(fā)疫苗或療法，這讓我很憤怒。不過既然現在發(fā)現它與致命且治療費用高昂的疾病有關聯，或許社會終于會重視治療手段的研發(fā)了，我期待治愈方法問世。
A compromised immune system is more likely to get colds and flu's, as are people low in Vitamin D who aren't as active as they should be.
免疫系統受損的人更容易感冒和患流感，缺乏維生素D或缺乏運動的人群也是如此。
Luckily Ive never had the flu, or mono. Covid once, and Strep Throat 5 years in a row as a child. Hopefully I dont get some crazy NDD they name Rowellism from all my Strep, wish me luck
幸運的是我從未得過流感或單核細胞增多癥。成年后感染過一次新冠，但小時候連續(xù)五年患鏈球菌性喉炎。希望這些鏈球菌感染不會讓我得個以我名字命名的神經退行性疾病"羅威爾癥"，祝我好運吧。
As a hypochondriac who suddonly has a bunch of actual, diagnosed issues after getting covid for the first time IN 2024.. i probably shouldnt watch this.
作為2024年首次感染新冠后突然確診多種疾病的疑病癥患者，我大概不該看這個視頻。
Thankfully I'm an oddity and almost never get the flu. It's been over a decade since I last had it. This is the only vax I don't need to get. I seem to be resistant to some virus. Colds are very mild.. It took the beginning of last year before I got covid for the first and only time. It was no worse than a cold. BUT now I'm extremely concerned we have idiots running the show AGAIN here in the States.
慶幸的是我體質特殊，幾乎從不感冒，上次得流感已是十多年前。這是我唯一不需要接種的疫苗。我對某些病毒似乎有抵抗力，即使感冒癥狀也很輕。直到去年初才首次感染新冠，癥狀和普通感冒差不多。但現在我非常擔心美國又讓蠢貨掌權了。
Flu isn't a disease! It's your body's response to a build up of toxins in your body, the flu is your bodies way of clearing out those toxins
流感不是疾??！它是身體對毒素堆積的反應，是身體自我排毒的方式。
as someone whose body was wrecked by the covid i caught in november of 2019, i sure hope not! i still cant breathe right and i have pots symptoms!
作為2019年11月感染新冠導致身體垮掉的人，我真心希望不是這樣！至今仍有呼吸困難及體位性心動過速癥狀！
The 1917 flu did skew the population such that those remaining were older, that may be one way to skew results.
Another way is that some people may be more susceptible flu because they lack the genes that make them safe from neurodegenerative diseases.
Could be that other health influences like food, or clean water, or even the stress from a pandemic can make survivors more susceptible to the flu...
Lots of reasons why numbers can skew in favorable/dexerious ways...
1918大流感導致人口結構老齡化，這可能影響研究結果。另一種可能是某些人因缺乏抗神經退行性病變基因而易感流感。其他因素如飲食、凈水供應、疫情壓力也可能提高幸存者流感易感性...數據偏差存在多種可能性。
I wish you had mentioned which HIV medication might treat ALS plaque. I contracted Mono because I had HIV. Because of my HIV treatment I am truly only concerned about developing MS due to contracting mono
希望你能說明哪種HIV藥物可能治療ALS斑塊。我因HIV感染而患上單核細胞增多癥，得益于抗HIV治療，現在唯一擔心的是單核細胞增多癥引發(fā)多發(fā)性硬化癥。
It gives me a little bit of comfort, seeing as I get my routine vaccinations each year, that my brain won't fall apart. However, I do still have symptoms of long covid, the most prominent being executive dysfunction. So uh. Jury's still out I guess.
每年定期接種疫苗讓我對大腦健康稍感安心，但仍有長期新冠癥狀，最明顯的是執(zhí)行功能障礙。所以...結論尚待觀察吧。
It's a good job that COVID doesn't cause NDDs then, seeing as almost everybody on the planet has had it.
幸好新冠不會導致神經退行性疾病，畢竟全球幾乎人人都感染過了。
But surely Americans are immune to Alzheimer what with their brains being mush already anyway.
美國人肯定對阿爾茨海默免疫啦，畢竟他們腦子早就成漿糊了。
Its really too bad vaccines are scary now to the uneducated halfwits that make up majority america otherwise we might be able to fix this
可悲的是美國多數愚民現在害怕疫苗，否則我們本可能解決這個問題。
I'm very confused by the introduction. While Parkinson's, Alzheimer's, and other types of dementia are, indeed, more common among the elderly, they have never been a consequence of aging. Decades of research suggests that these disorders can develop as a result of genetic predispositions, substance use/exposure, or having certain virus-triggered diseases.
開頭讓我很困惑。雖然帕金森、阿爾茨海默等癡呆癥在老年人中更常見，但從來不是衰老的必然結果。數十年研究表明這些疾病源于遺傳傾向、物質濫用/暴露或特定病毒觸發(fā)。
If only we had a National Institute of Health that could fund research...
要是我們有個能資助研究的國家衛(wèi)生研究院就好了...
That part in the beginning about people assuming neurodegenerative diseases are a part of life reminds me of type 1 diabetes. Something that is often caused by the flu, but theres a pervasive myth that people are born with it. There are some rare genetic disorders that seem to cause type 1 but not nearly as much as flu infections.
開頭提到人們認為神經退行性疾病是人生必經階段，這讓我想到I型糖尿病。它常由流感引發(fā)，但普遍誤傳為先天疾病。雖有罕見遺傳病例，但遠少于流感誘發(fā)病例。
原創(chuàng)翻譯：龍騰網 http://www.top-shui.cn 轉載請注明出處
what if its the other way around, people with high risk of alzheimer are more prone to having severe flu
如果是反過來的情況呢？阿爾茨海默高風險人群可能更易患重癥流感。
Since some vaccines use a live deactivated virus and some use a dead virus, could there be a lix to the vaccines also contributing to this?
既然有些疫苗使用滅活病毒，有些使用死病毒，是否疫苗本身也可能與此有關？
My brain has Alzheimer's from that cold last year i tell ya, they tested for everything but came back negative everywhere. I just told everyone in the family it was birdflu ?. But having a temp over 101 for six weeks is BULL S?
我敢說去年那場感冒讓我得了阿爾茨海默，雖然所有檢測都陰性。我只好跟家人說是禽流感，但連續(xù)六周高燒41度以上真是見鬼了。
Oh boy, severe case of chicken pox, the vid and two severe bouts of flu and Ive had an essential tremor as long as I can remember. Seems the writing is on my wall
天啊，我得過嚴重水痘、兩次重癥流感，從小就有原發(fā)性震顫，看來命運早已寫好結局。